Synthesis and Anti-Denaturation Activity of Some Substituted Quinazolinone Analogs
نویسندگان
چکیده
In recent years there is a tremendous increase of inflammatory cases, leading to the design and development of newer anti-inflammatory agents. The reaction of 2-substituted phenyl-3-chloroacetamido quinazolin-4(3H)-ones with various 5-phenyl-1,3,4-oxadiazole-2-thiol and 5-(pyridine-4-yl)-1,3,4-oxadiazole-2thiol gave N-(4-Oxo-2-substituted phenylquinazolin-3(4H)-yl)-2-[(5-aryl-1,3,4-oxadiazol-2-yl)sulfanyl] acetamides derivatives. The reaction of 2-phenyl-3-chloroacetamido quinazolinone with various heteroaryl thiols and amines gave N-(4-oxo-2-phenyl quinazolin-3(4H)-yl)-2-[(substituted amino/thiol] acetamide derivatives. The structure of all the compounds has been confirmed by IR, HNMR, Mass spectral data and elemental analysis. Invitro anti-inflammatory activity was performed by bovine serum albumin method. Some of the compounds have shown good antibacterial activity and few have shown moderate antioxidant activity compared to the standard drug.
منابع مشابه
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